| # | Team | MP | W | D | L | GD | Pts |
|---|---|---|---|---|---|---|---|
| 1 |  Philadelphia Union | 34 | 20 | 6 | 8 | 22 | 66 |
| 2 |  FC Cincinnati | 34 | 20 | 5 | 9 | 12 | 65 |
| 3 |  Inter Miami | 34 | 19 | 8 | 7 | 26 | 65 |
| 4 |  Charlotte | 34 | 19 | 2 | 13 | 9 | 59 |
| 5 |  New York City | 34 | 17 | 5 | 12 | 6 | 56 |
| 6 |  Nashville FC | 34 | 16 | 6 | 12 | 13 | 54 |
| 7 |  Columbus Crew | 34 | 14 | 12 | 8 | 4 | 54 |
| 8 |  Chicago Fire | 34 | 15 | 8 | 11 | 8 | 53 |
| 9 |  Orlando City | 34 | 14 | 11 | 9 | 12 | 53 |
| 10 |  New York RB | 34 | 12 | 7 | 15 | 1 | 43 |
| 11 |  New England | 34 | 9 | 9 | 16 | -7 | 36 |
| 12 |  Toronto | 34 | 6 | 14 | 14 | -7 | 32 |
| 13 |  Montréal | 34 | 6 | 10 | 18 | -26 | 28 |
| 14 |  Atlanta United | 34 | 5 | 13 | 16 | -25 | 28 |
| 15 |  D.C. United | 34 | 5 | 11 | 18 | -36 | 26 |
Head to Head
5
Nashville FC wins
3
Draws
4
Philadelphia Union wins
Goals: 13 - 12